The Benjamin G. Neel Laboratory studies cell signaling, with a particular emphasis on protein-tyrosine phosphatases (PTPs). The roles of the SH2 domain-containing phosphatase Shp2 and its binding proteins in several human diseases are a major focus. We also have a interest in breast and ovarian cancer biology. The lab utilizes a wide array of technologies, including shRNA and CRISPR screens, cell biology, proteomics, flow cytometry, organoids, patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMMs).
Keywords: SHP2, SHP1, PTP1B, PTPN11, PTPN1, PTPN6, RAS, ERK, RAF, MAPK, Rasopathies, Hypoxia, Moyamoya Disease, RNF213, ovarian cancer, breast cancer, HER2, organoids, mouse models, GEMMs.